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A hedge is an investment position intended to offset potential losses or gains that may be incurred by a companion investment.In simple language, a hedge is used to reduce any substantial losses or gains suffered by an individual or an organization.Randomized clinical trials (RCTs) are usually the preferred strategy with which to generate evidence of comparative effectiveness, but conducting an RCT is not always feasible.Though observational studies and RCTs often provide comparable estimates, the questioning of observational analyses has recently intensified because of randomized-observational discrepancies regarding the effect of postmenopausal hormone replacement therapy on coronary heart disease.

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replacement therapy led to attenuated discrepancies, which begs the question of whether exclusion of prevalent users should be generally recommended.In the current study, the authors evaluated the effect of excluding prevalent users of statins in a meta-analysis of observational studies of persons with cardiovascular disease.Chris’s FAB 1 Million project (he may have mentioned it once or twice) is officially under way with the pink Rolls-Royce Ghost, tastefully designed inside and out to resemble Lady Penelope’s Roller from Thunderbirds, available for hire from £5,000 a day and every penny raised going to Breast Cancer Care.Some premium hire packages include entry to Silverstone, Goodwood, Royal Ascot and other events. First deliveries of BMW’s updated Z4 roadster are happening around now.

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